Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study.

ABSTRACT: Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case-control study in a cohort of African American women to replicate and narrow the region carrying the causal variant(s). We evaluated 14 tagging SNPs in a 98 kb LD block surrounding the index SNPs in 886 breast cancer cases and 1,089 controls from the Black Women's Health Study. We used the Cochran-Armitage trend test to assess association with breast cancer risk. Odds ratios were derived from logistic regression analyses adjusted for potential confounders including

SUBMITTER: Ruiz-Narvaez EA 

PROVIDER: S-EPMC3208423 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature