Ontology highlight
ABSTRACT:
SUBMITTER: Boilard E
PROVIDER: S-EPMC3208424 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Boilard Eric E Larabee Katherine K Shnayder Ruslan R Jacobs Kathleen K Farndale Richard W RW Ware Jerry J Lee David M DM
Journal of immunology (Baltimore, Md. : 1950) 20110228 7
In addition to the well-described role of platelets in thrombosis, a growing body of evidence implicates platelets in diverse inflammatory responses. We recently showed platelets can contribute to the pathophysiology of inflammatory arthritis via IL-1- containing microparticles. In this study, we demonstrate that platelets, and not platelet microparticles, actively contribute to synovitis via production of proinflammatory prostacyclin in an autoimmune arthritis model. Using both genetic and phar ...[more]