Dataset Information
Long-term exposure to air pollution and cardiorespiratory disease in the California teachers study cohort.
Ontology highlight
ABSTRACT: Rationale
Several studies have linked long-term exposure to particulate air pollution with increased cardiopulmonary mortality; only two have also examined incident circulatory disease.Objectives
To examine associations of individualized long-term exposures to particulate and gaseous air pollution with incident myocardial infarction and stroke, as well as all-cause and cause specific mortality.Methods
We estimated long-term residential air pollution exposure for more than 100,000 participants in the California Teachers Study, a prospective cohort of female public school professionals.We linked geocoded residential addresses with inverse distance-weighted monthly pollutant surfaces for two measures of particulate matter and for several gaseous pollutants. We examined associations between exposure to these pollutants and risks of incident myocardial infarction and stroke, and of all-cause and cause-specific mortality, using Cox proportional hazards models.Measurements and main results
We found elevated hazard ratios linking long-term exposure to particulate matter less than 2.5 ?m in aerodynamic diameter (PM2.5), scaled to an increment of 10 ?g/m3 with mortality from ischemic heart disease (IHD) (1.20; 95% confidence interval [CI], 1.02-1.41) and, particularly among postmenopausal women, incident stroke (1.19; 95% CI, 1.02-1.38). Long-term exposure to particulate matter less than 10 ?m in aerodynamic diameter (PM10) was associated with elevated risks for IHD mortality (1.06; 95% CI, 0.99-1.14) and incident stroke (1.06; 95% CI, 1.00-1.13), while exposure to nitrogen oxides was associated with elevated risks for IHD and all cardiovascular mortality.Conclusions
This study provides evidence linking long-term exposure to PM2.5 and PM10 with increased risks of incident stroke as well as IHD mortality; exposure to nitrogen oxides was also related to death from cardiovascular diseases.
SUBMITTER: Lipsett MJ
PROVIDER: S-EPMC3208653 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Long-term exposure to air pollution and cardiorespiratory disease in the California teachers study cohort.
American journal of respiratory and critical care medicine 20111001 7
<h4>Rationale</h4>Several studies have linked long-term exposure to particulate air pollution with increased cardiopulmonary mortality; only two have also examined incident circulatory disease.<h4>Objectives</h4>To examine associations of individualized long-term exposures to particulate and gaseous air pollution with incident myocardial infarction and stroke, as well as all-cause and cause specific mortality.<h4>Methods</h4>We estimated long-term residential air pollution exposure for more than ...[more]