Ontology highlight
ABSTRACT:
SUBMITTER: Corthals SL
PROVIDER: S-EPMC3208695 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Corthals Sophie L SL Kuiper Rowan R Johnson David C DC Sonneveld Pieter P Hajek Roman R van der Holt Bronno B Magrangeas Florence F Goldschmidt Hartmut H Morgan Gareth J GJ Avet-Loiseau Hervé H
Haematologica 20110726 11
Bortezomib induced peripheral neuropathy is a dose-limiting side effect and a major concern in the treatment of multiple myeloma. To identify genetic risk factors associated with the development of this side effect in bortezomib treated multiple myeloma patients, a pharmacogenetic association study was performed using a discovery set (IFM 2005-01; n = 238) and a validation set (HOVON65/GMMG-HD4 and a Czech dataset; n = 231). After multiplicity correction, none of the 2,149 single nucleotide poly ...[more]