Ontology highlight
ABSTRACT:
SUBMITTER: Draber P
PROVIDER: S-EPMC3209250 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Draber Peter P Vonkova Ivana I Stepanek Ondrej O Hrdinka Matous M Kucova Marketa M Skopcova Tereza T Otahal Pavel P Angelisova Pavla P Horejsi Vaclav V Yeung Mandy M Weiss Arthur A Brdicka Tomas T
Molecular and cellular biology 20110919 22
Formation of the immunological synapse between an antigen-presenting cell (APC) and a T cell leads to signal generation in both cells involved. In T cells, the lipid raft-associated transmembrane adaptor protein LAT plays a central role. Its phosphorylation is a crucial step in signal propagation, including the calcium response and mitogen-activated protein kinase activation, and largely depends on its association with the SLP76 adaptor protein. Here we report the discovery of a new palmitoylate ...[more]