CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission.
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ABSTRACT:
SUBMITTER: Mudd PA
PROVIDER: S-EPMC3209381 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission.
Mudd Philip A PA Ericsen Adam J AJ Walsh Andrew D AD León Enrique J EJ Wilson Nancy A NA Maness Nicholas J NJ Friedrich Thomas C TC Watkins David I DI
Journal of virology 20110928 23
Virus-specific CD8(+) T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex class I [MHC-I] molecules) in three different viruses. Two of these MHC-I alleles are associated with elite control. Two of the three viruses demonstrated reduced fitness in vivo, and 27% of the introdu ...[more]
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