Ontology highlight
ABSTRACT:
SUBMITTER: Sczesnak A
PROVIDER: S-EPMC3209701 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Sczesnak Andrew A Segata Nicola N Qin Xiang X Gevers Dirk D Petrosino Joseph F JF Huttenhower Curtis C Littman Dan R DR Ivanov Ivaylo I II
Cell host & microbe 20110901 3
Perturbations of the composition of the symbiotic intestinal microbiota can have profound consequences for host metabolism and immunity. In mice, segmented filamentous bacteria (SFB) direct the accumulation of potentially proinflammatory Th17 cells in the intestinal lamina propria. We present the genome sequence of SFB isolated from monocolonized mice, which classifies SFB phylogenetically as a unique member of Clostridiales with a highly reduced genome. Annotation analysis demonstrates that SFB ...[more]