Ontology highlight
ABSTRACT:
SUBMITTER: Castro-Castro A
PROVIDER: S-EPMC3209784 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20110826 19
The activation of the Rac1 GTPase during cell signalling entails its translocation from the cytosol to membranes, release from sequestering Rho GDP dissociation inhibitors (RhoGDI), and GDP/GTP exchange. In addition to those steps, we show here that optimal Rac1 activation during cell signalling requires the engagement of a downstream, cytoskeletal-based feedback loop nucleated around the cytoskeletal protein coronin 1A and the Rac1 exchange factor ArhGEF7. These two proteins form a cytosolic co ...[more]