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Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes.

ABSTRACT: A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupling reactions can be applied to the halogenated products to generate a structurally diverse library of indazoles.

SUBMITTER: Fang Y

PROVIDER: S-EPMC3209955 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Synthesis of 2H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes.

Fang Yuesi Y Wu Chunrui C Larock Richard C RC Shi Feng F

The Journal of organic chemistry 20111012 21

A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupling reactions can be applied to the halogenated products to generate a structurally diverse library of indazoles. ...[more]

PMID: 21970468

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