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Gene therapy for lung neoplasms.

ABSTRACT: Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review considers the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.

SUBMITTER: Vachani A

PROVIDER: S-EPMC3210443 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Gene therapy for lung neoplasms.

Vachani Anil A Moon Edmund E Wakeam Elliot E Haas Andrew R AR Sterman Daniel H DH Sterman Daniel H DH Albelda Steven M SM

Clinics in chest medicine 20111007 4

Both advanced-stage lung cancer and malignant pleural mesothelioma are associated with a poor prognosis. Advances in treatment regimens for both diseases have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in several clinical trials. Strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination appr ...[more]

PMID: 22054892

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