Ontology highlight
ABSTRACT:
SUBMITTER: Niu TK
PROVIDER: S-EPMC3210451 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Niu Ting-Kuang TK Cheng Yan Y Ren Xingcong X Yang Jin-Ming JM
FEBS letters 20100716 16
We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates t ...[more]