Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3210610 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Li Jing J Zhang Dingmei D Zhu Xun X He Zhenjian Z Liu Shu S Li Mengfeng M Pang Jiyan J Lin Yongcheng Y
Marine drugs 20111011 10
Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1), 27.73 μM for A/Guangdong/03/2009 (H1N1), and 25.13 μM for A/Guangdong/ 05/2009 (H1N1), respectively, which is stronger than the benzoic acid derivatives (~mM ...[more]