Plague bacteria target immune cells during infection.
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ABSTRACT:
SUBMITTER: Marketon MM
PROVIDER: S-EPMC3210820 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Publications
Plague bacteria target immune cells during infection.
Marketon Melanie M MM DePaolo R William RW DeBord Kristin L KL Jabri Bana B Schneewind Olaf O
Science (New York, N.Y.) 20050728 5741
The plague is caused by the bacterium Yersinia pestis. Plague bacteria are thought to inject effector Yop proteins into host cells via the type III pathway. The identity of the host cells targeted for injection during plague infection is unknown. We found, using Yop beta-lactamase hybrids and fluorescent staining of live cells from plague-infected animals, that Y. pestis selected immune cells for injection. In vivo, dendritic cells, macrophages, and neutrophils were injected most frequently, whe ...[more]
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