Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.
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ABSTRACT:
SUBMITTER: Teplyakov A
PROVIDER: S-EPMC3212354 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.
Teplyakov Alexey A Obmolova Galina G Malia Thomas T Gilliland Gary G
Acta crystallographica. Section F, Structural biology and crystallization communications 20110924 Pt 10
C836 is a neutralizing monoclonal antibody to human interleukin IL-13 generated by mouse immunization. The crystal structure of the C836 Fab was determined at 2.5 Å resolution and compared with the IL-13-bound form determined previously. This comparison indicates an induced-fit mechanism of antigen recognition through rigid-body rotation of the V(L) and V(H) domains. The magnitude of this rearrangement is one of the largest observed for antibody-protein interactions. ...[more]
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