Ontology highlight
ABSTRACT:
SUBMITTER: Yoga YM
PROVIDER: S-EPMC3212377 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Yoga Yano M K YM Traore Daouda A K DA Wilce Jacqueline A JA Wilce Matthew C J MC
Acta crystallographica. Section F, Structural biology and crystallization communications 20110930 Pt 10
Polycytosine-binding proteins (PCBPs) are triple KH-domain proteins that play an important role in the regulation of translation of eukaryotic mRNA. They are also utilized by viral RNA and have been shown to interact with ssDNA. Underlying their function is the specific recognition of C-rich nucleotides by their KH domains. However, the structural basis of this recognition is only partially understood. Here, the preparation of a His-tagged KH domain is described, representing the first domain of ...[more]