Mutagen-specific mutation signature determines global microRNA binding.
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ABSTRACT:
SUBMITTER: Greenberg E
PROVIDER: S-EPMC3212558 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Mutagen-specific mutation signature determines global microRNA binding.
Greenberg Eyal E Rechavi Gideon G Amariglio Ninette N Solomon Oz O Schachter Jacob J Markel Gal G Eyal Eran E
PloS one 20111109 11
Micro-RNAs (miRNAs) are small non-coding RNAs that regulate gene products at the post-transcriptional level. It is thought that loss of cell regulation by miRNAs supports cancer development. Based on whole genome sequencing of a melanoma tumor, we predict, using three different computational algorithms, that the melanoma somatic mutations globally reduce binding of miRNAs to the mutated 3'UTRs. This phenomenon reflects the nature of the characteristic UV-induced mutation, C-to-T. Furthermore, we ...[more]
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