Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells.

ABSTRACT: Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression profiles in post-ischaemic myocardium treated with BMNC transplantation. BMNC suspensions were injected into cardiac scar tissue 10 days after experimental myocardial infarction. Six weeks later, mice undergoing BMNC therapy were found to have normalized antibody repertoire and improved cardiac performance measured by ECG, treadmill exercise time and echocardiography. After functional testing, gene expression profiles in cardiac tissue were evaluated using high-density oligonucleo

SUBMITTER: Lachtermacher S 

PROVIDER: S-EPMC3212608 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature