Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3212682 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.
Wang Xiaoling X Prins Bram P BP Sõber Siim S Laan Maris M Snieder Harold H
Current hypertension reports 20111201 6
Genetic linkage and association methods have long been the most important tools for gene identification in humans. These approaches can either be hypothesis-based (i.e., candidate-gene studies) or hypothesis-free (i.e., genome-wide studies). The first part of this review offers an overview of the latest successes in gene finding for blood pressure (BP) and essential hypertension using these DNA sequence-based discovery techniques. We further emphasize the importance of post-genome-wide associati ...[more]
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