New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.
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ABSTRACT:
SUBMITTER: Matsumoto H
PROVIDER: S-EPMC3212863 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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New short term prediction method for chemical carcinogenicity by hepatic transcript profiling following 28-day toxicity tests in rats.
Matsumoto Hiroshi H Yakabe Yoshikuni Y Saito Fumiyo F Saito Koichi K Sumida Kayo K Sekijima Masaru M Nakayama Koji K Miyaura Hideki H Otsuka Masanori M Shirai Tomoyuki T
Cancer informatics 20111027
We have previously shown the hepatic gene expression profiles of carcinogens in 28-day toxicity tests were clustered into three major groups (Group-1 to 3). Here, we developed a new prediction method for Group-1 carcinogens which consist mainly of genotoxic rat hepatocarcinogens. The prediction formula was generated by a support vector machine using 5 selected genes as the predictive genes and predictive score was introduced to judge carcinogenicity. It correctly predicted the carcinogenicity of ...[more]
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