Ontology highlight
ABSTRACT:
SUBMITTER: Kadonosono T
PROVIDER: S-EPMC3213102 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Kadonosono Tetsuya T Kuchimaru Takahiro T Yamada Shuichi S Takahashi Yumi Y Murakami Atsushi A Tani Taeko T Watanabe Hitomi H Tanaka Tomoharu T Hirota Kiichi K Inoue Masahiro M Tsukamoto Tetsuya T Toyoda Takeshi T Urano Koji K Machida Kazuhiko K Eto Tomoo T Ogura Tomoyuki T Tsutsumi Hideki H Ito Mamoru M Hiraoka Masahiro M Kondoh Gen G Kizaka-Kondoh Shinae S
PloS one 20111110 11
An animal model for the early detection of common fatal diseases such as ischemic diseases and cancer is desirable for the development of new drugs and treatment strategies. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in a number of diseases, including cancer. Here, we established transgenic (Tg) mice that carry HRE/ODD-luciferase (HOL) gene, which generates bioluminescence in an HIF-1-dependent manner and was successfully us ...[more]