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The efferent medial olivocochlear-hair cell synapse.


ABSTRACT: Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of ?9 and ?10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.

SUBMITTER: Elgoyhen AB 

PROVIDER: S-EPMC3213294 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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The efferent medial olivocochlear-hair cell synapse.

Elgoyhen Ana Belén AB   Katz Eleonora E  

Journal of physiology, Paris 20110706 1-2


Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of  ...[more]

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