Ontology highlight
ABSTRACT:
SUBMITTER: Gotte DR
PROVIDER: S-EPMC3214077 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Götte Dorothea R DR Benestad Sylvie L SL Laude Hubert H Zurbriggen Andreas A Oevermann Anna A Seuberlich Torsten T
PloS one 20111111 11
The pathobiology of atypical scrapie, a prion disease affecting sheep and goats, is still poorly understood. In a previous study, we demonstrated that atypical scrapie affecting small ruminants in Switzerland differs in the neuroanatomical distribution of the pathological prion protein (PrP(d)). To investigate whether these differences depend on host-related vs. pathogen-related factors, we transmitted atypical scrapie to transgenic mice over-expressing the ovine prion protein (tg338). The clini ...[more]