Ontology highlight
ABSTRACT:
SUBMITTER: Paluszkiewicz SM
PROVIDER: S-EPMC3214096 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Paluszkiewicz Scott M SM Olmos-Serrano Jose Luis JL Corbin Joshua G JG Huntsman Molly M MM
Journal of neurophysiology 20110727 5
Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by severe cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy. Fmr1 knockout (KO) mouse models of FXS exhibit alterations in excitatory and inhibitory neurotransmission, but it is largely unknown how aberrant function of specific neuronal subtypes contributes to these deficits. In this study we show specific inhibitory circuit dysfunction in layer II/III of somatosensory cortex of Fmr1 ...[more]