Ontology highlight
ABSTRACT:
SUBMITTER: Boogerd CJ
PROVIDER: S-EPMC3214269 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Boogerd C J J CJ Wong L Y E LY van den Boogaard M M Bakker M L ML Tessadori F F Bakkers J J 't Hoen P A C PA Moorman A F AF Christoffels V M VM Barnett P P
Cellular and molecular life sciences : CMLS 20110503 23
Tbx3, a T-box transcription factor, regulates key steps in development of the heart and other organ systems. Here, we identify Sox4 as an interacting partner of Tbx3. Pull-down and nuclear retention assays verify this interaction and in situ hybridization reveals Tbx3 and Sox4 to co-localize extensively in the embryo including the atrioventricular and outflow tract cushion mesenchyme and a small area of interventricular myocardium. Tbx3, SOX4, and SOX2 ChIP data, identify a region in intron 1 of ...[more]