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Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-? from induced inflammasomes.

ABSTRACT: The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation of berkeleydione (1), berkeleytrione (2), the berkeleyacetals, and the berkeleyamides from the Pit Lake fungus Penicillium rubrum. In this paper we report the isolation and characterization of berkeleyones A-C (4, 5, and 7) as well as previously described preaustinoid A (3) and A1(6) from this same fungus. These compounds were evaluated as inhibitors of the signaling enzyme caspase-1 and as potential inhibitors of interleukin 1-? production by inflammasomes in induced THP-1 cell line assays.

SUBMITTER: Stierle DB

PROVIDER: S-EPMC3214658 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Berkeleyones and related meroterpenes from a deep water acid mine waste fungus that inhibit the production of interleukin 1-β from induced inflammasomes.

Stierle Donald B DB Stierle Andrea A AA Patacini Brianna B McIntyre Kyle K Girtsman Teri T Bolstad Erin E

Journal of natural products 20110914 10

The Berkeley Pit, an acid mine waste lake, is a source of extremophilic microorganisms that produce interesting bioactive compounds. We have previously reported the isolation of berkeleydione (1), berkeleytrione (2), the berkeleyacetals, and the berkeleyamides from the Pit Lake fungus Penicillium rubrum. In this paper we report the isolation and characterization of berkeleyones A-C (4, 5, and 7) as well as previously described preaustinoid A (3) and A1(6) from this same fungus. These compounds w ...[more]

PMID: 21916432

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