Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes.
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ABSTRACT:
SUBMITTER: Mi X
PROVIDER: S-EPMC3215172 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
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Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes.
Mi Xiaofan X He Hongzhi H Deng Yangxin Y Levin Abert M AM She Jin-Xiong JX Mi Qing-Sheng QS Zhou Li L
Diabetology & metabolic syndrome 20111020 1
MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed ...[more]
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