Ontology highlight
ABSTRACT:
SUBMITTER: Cianci C
PROVIDER: S-EPMC321540 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Cianci Christopher C Yu Kuo-Long KL Combrink Keith K Sin Ny N Pearce Bradley B Wang Alan A Civiello Rita R Voss Stacey S Luo Guangxiang G Kadow Kathy K Genovesi Eugene V EV Venables Brian B Gulgeze Hatice H Trehan Ashok A James Jennifer J Lamb Lucinda L Medina Ivette I Roach Julia J Yang Zheng Z Zadjura Lisa L Colonno Richard R Clark Junius J Meanwell Nicholas N Krystal Mark M
Antimicrobial agents and chemotherapy 20040201 2
BMS-433771 was found to be a potent inhibitor of respiratory syncytial virus (RSV) replication in vitro. It exhibited excellent potency against multiple laboratory and clinical isolates of both group A and B viruses, with an average 50% effective concentration of 20 nM. Mechanism-of-action studies demonstrated that BMS-433771 inhibits the fusion of lipid membranes during both the early virus entry stage and late-stage syncytium formation. After isolation of resistant viruses, resistance was mapp ...[more]