Ontology highlight
ABSTRACT:
SUBMITTER: Bavagnoli L
PROVIDER: S-EPMC3215730 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Bavagnoli Laura L Dundon William G WG Garbelli Anna A Zecchin Bianca B Milani Adelaide A Parakkal Geetha G Baldanti Fausto F Paolucci Stefania S Volmer Romain R Tu Yizeng Y Wu Chuanyue C Capua Ilaria I Maga Giovanni G
PloS one 20111114 11
The Non-structural 1 (NS1) protein of avian influenza (AI) viruses is important for pathogenicity. Here, we identify a previously unrecognized tandem PDZ-ligand (TPL) domain in the extreme carboxy terminus of NS1 proteins from a subset of globally circulating AI viruses. By using protein arrays we have identified several human PDZ-cellular ligands of this novel domain, one of which is the RIL protein, a known regulator of the cellular tyrosine kinase Src. We found that the AI NS1 proteins bind a ...[more]