GSK3? is involved in the relief of mitochondria pausing in a Tau-dependent manner.
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ABSTRACT:
SUBMITTER: Llorens-Martin M
PROVIDER: S-EPMC3215736 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner.
Llorens-Martín María M López-Doménech Guillermo G Soriano Eduardo E Avila Jesús J
PloS one 20111114 11
Mitochondrial trafficking deficits have been implicated in the pathogenesis of several neurological diseases, including Alzheimer's disease (AD). The Ser/Thre kinase GSK3β is believed to play a fundamental role in AD pathogenesis. Given that GSK3β substrates include Tau protein, here we studied the impact of GSK3β on mitochondrial trafficking and its dependence on Tau protein. Overexpression of GSK3β in neurons resulted in an increase in motile mitochondria, whereas a decrease in the activity of ...[more]
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