Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez G
PROVIDER: S-EPMC3215777 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Hernández Gonzalo G Lal Hind H Fidalgo Miguel M Guerrero Ana A Zalvide Juan J Force Thomas T Pombo Celia M CM
Experimental cell research 20111002 20
Despite intensive study, the mechanisms regulating activation of mTOR and the consequences of that activation in the ischemic heart remain unclear. This is particularly true for the setting of ischemia/reperfusion (I/R) injury. In a mouse model of I/R injury, we observed robust mTOR activation, and its inhibition by rapamycin increased injury. Consistent with the in-vivo findings, mTOR activation was also protective in isolated cardiomyocytes exposed to two models of I/R. Moreover, we identify a ...[more]