Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.
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ABSTRACT: Objective
To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants.Study design
Infants with birth weights ?1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1?; IL-8; tumor necrosis factor-?; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants.Results
IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-?, soluble IL r?, macrophage inflammatory protein 1?) were found to be altered on days 0-4 in infants who developed CP.Conclusions
CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
SUBMITTER: Carlo WA
PROVIDER: S-EPMC3215787 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.
Carlo Waldemar A WA McDonald Scott A SA Tyson Jon E JE Stoll Barbara J BJ Ehrenkranz Richard A RA Shankaran Seetha S Goldberg Ronald N RN Das Abhik A Schendel Diana D Thorsen Poul P Skogstrand Kristin K Hougaard David M DM Oh William W Laptook Abbot R AR Duara Shahnaz S Fanaroff Avroy A AA Donovan Edward F EF Korones Sheldon B SB Stevenson David K DK Papile Lu-Ann LA Finer Neil N NN O'Shea T Michael TM Poindexter Brenda B BB Wright Linda L LL Ambalavanan Namasivayam N Higgins Rosemary D RD
The Journal of pediatrics 20110727 6
<h4>Objective</h4>To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants.<h4>Study design</h4>Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analys ...[more]
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