Ontology highlight
ABSTRACT:
SUBMITTER: Maures TJ
PROVIDER: S-EPMC3215905 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Maures Travis J TJ Greer Eric L EL Hauswirth Anna G AG Brunet Anne A
Aging cell 20110916 6
Aging is accompanied by alterations in epigenetic marks that control chromatin states, including histone acetylation and methylation. Enzymes that reversibly affect histone marks associated with active chromatin have recently been found to regulate aging in Caenorhabditis elegans. However, relatively little is known about the importance for aging of histone marks associated with repressed chromatin. Here, we use a targeted RNAi screen in C. elegans to identify four histone demethylases that sign ...[more]