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An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.


ABSTRACT: Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.

SUBMITTER: Zhang G 

PROVIDER: S-EPMC3216508 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.

Zhang Guoliang G   Chen Xinchun X   Chan Long L   Zhang Mingxia M   Zhu Baohua B   Wang Lantian L   Zhu Xiuyun X   Zhang Jieyun J   Zhou Boping B   Wang Junwen J  

Scientific reports 20110621


Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The S  ...[more]

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