Ontology highlight
ABSTRACT:
SUBMITTER: Zhang G
PROVIDER: S-EPMC3216508 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Zhang Guoliang G Chen Xinchun X Chan Long L Zhang Mingxia M Zhu Baohua B Wang Lantian L Zhu Xiuyun X Zhang Jieyun J Zhou Boping B Wang Junwen J
Scientific reports 20110621
Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The S ...[more]