Ontology highlight
ABSTRACT:
SUBMITTER: Spaccapelo R
PROVIDER: S-EPMC3216526 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Spaccapelo Roberta R Aime Elena E Caterbi Sara S Arcidiacono Paola P Capuccini Barbara B Di Cristina Manlio M Dottorini Tania T Rende Mario M Bistoni Francesco F Crisanti Andrea A
Scientific reports 20110718
Blood stage malaria parasites causing a mild and self limited infection in mice have been obtained with either radiation or chemical mutagenesis showing the possibility of developing an attenuated malaria vaccine. Targeted disruption of plasmepsin-4 (pm4) or the merozoite surface protein-7 (msp7) genes also induces a virulence-attenuated phenotype in terms of absence of experimental cerebral malaria (ECM), delayed increase of parasitemia and reduced mortality rate. The decrease in virulence in p ...[more]