Exploring and challenging the network of angiogenesis.
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ABSTRACT:
SUBMITTER: Montanez R
PROVIDER: S-EPMC3216548 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Exploring and challenging the network of angiogenesis.
Montañez Raúl R Sánchez-Jiménez Francisca F Quesada Ana R AR Medina Miguel Ángel MÁ
Scientific reports 20110811
Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a network approach would be a convenient systemic way to analyse responses to directed drug attacks. Herein we show that, although the angiogenic network is easily broken by short combinations of directed attacks, it still remains essentially functional by keeping the global patter ...[more]
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