Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki R
PROVIDER: S-EPMC3216614 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Suzuki Rintaro R Fujimoto Zui Z Shiotsuki Takahiro T Tsuchiya Wataru W Momma Mitsuru M Tase Akira A Miyazawa Mitsuhiro M Yamazaki Toshimasa T
Scientific reports 20111028
Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of apo and JH-bound JHBP. In solution, apo-JHBP exists in equilibrium of multiple conformations with different orientations of the gate helix for the hormone-binding pocket ranging fr ...[more]