The metabolic footprint of aging in mice.
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ABSTRACT:
SUBMITTER: Houtkooper RH
PROVIDER: S-EPMC3216615 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
The metabolic footprint of aging in mice.
Houtkooper Riekelt H RH Argmann Carmen C Houten Sander M SM Cantó Carles C Jeninga Ellen H EH Andreux Pénélope A PA Thomas Charles C Doenlen Raphaël R Schoonjans Kristina K Auwerx Johan J
Scientific reports 20111031
Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, metabolic dysfunction is a common hallmark of aging at least in invertebrates. Since a comprehensive overview of metabolic changes in otherwise healthy aging mammals is lacking, we here compared metabolic parameters of young and 2 year old mice. We systemically integrated in vivo phenotyping with gene expression, ...[more]
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