Ontology highlight
ABSTRACT:
SUBMITTER: de Souza FM
PROVIDER: S-EPMC3216618 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
de Souza Fabio M Simoes FM Busquet Nicolas N Blatner Megan M Maclean Kenneth N KN Restrepo Diego D
Scientific reports 20111102
Down syndrome (DS) is the most common form of congenital intellectual disability. Although DS involves multiple disturbances in various tissues, there is little doubt that in terms of quality of life cognitive impairment is the most serious facet and there is no effective treatment for this aspect of the syndrome. The Ts65Dn mouse model of DS recapitulates multiple aspects of DS including cognitive impairment. Here the Ts65Dn mouse model of DS was evaluated in an associative learning paradigm ba ...[more]