Ontology highlight
ABSTRACT:
SUBMITTER: Sisirak V
PROVIDER: S-EPMC3217401 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Sisirak Vanja V Vey Nelly N Vanbervliet Béatrice B Duhen Thomas T Puisieux Isabelle I Homey Bernhard B Bowman Edward P EP Trinchieri Giorgio G Dubois Bertrand B Kaiserlian Dominique D Lira Sergio A SA Puisieux Alain A Blay Jean-Yves JY Caux Christophe C Bendriss-Vermare Nathalie N
Blood 20110921 19
Absent in peripheral tissues during homeostasis, human plasmacytoid dendritic cells (pDCs) are described in inflamed skin or mucosa. Here, we report that, unlike blood pDCs, a subset of tonsil pDCs express functional CCR6 and CCR10, and their respective ligands CCL20 and CCL27are detected in inflamed epithelia contacting blood dendritic cell antigen 2(+) pDCs. Moreover, pDCs are recruited to imiquimod-treated skin tumors in WT but not CCR6-deficient mice, and competitive adoptive transfers revea ...[more]