Ontology highlight
ABSTRACT:
SUBMITTER: Gong IY
PROVIDER: S-EPMC3218053 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gong Inna Y IY Schwarz Ute I UI Crown Natalie N Dresser George K GK Lazo-Langner Alejandro A Zou GuangYong G Roden Dan M DM Stein C Michael CM Rodger Marc M Wells Philip S PS Kim Richard B RB Tirona Rommel G RG
PloS one 20111116 11
Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S-warfarin plasma levels and international normalized ratio were obtained to serve as inputs to a pharmacokinetic-pharmacodynamic (PK-PD) model. Individual PK (S-warfarin clearance) and PD (I(max)) par ...[more]