Genetic variation in inflammatory pathways is related to colorectal cancer survival.

ABSTRACT:

Purpose

Prognosis of patients with colorectal cancer (CRC) is associated with systemic inflammation, and anti-inflammatory drugs can reduce both CRC incidence and mortality. Genetic variation in proinflammatory pathways can affect an individual's CRC risk. However, few studies have investigated the prognostic importance of this genetic variation in CRC patients.

Experimental design

We investigated the association between CRC survival and genetic variation in proinflammatory pathways among patients from the Puget Sound Surveillance Epidemiology and End Results registry. Single-nucleotide polymorphisms were genotyped in five genes (PTGS-1, PTGS-2, MRP4, NFκB, and IκBKβ). Vital status was ascertained through linkage to the National Death Index. Cox proportional hazards regressi

SUBMITTER: Coghill AE 

PROVIDER: S-EPMC3218294 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature