Ontology highlight
ABSTRACT:
SUBMITTER: Hansen TB
PROVIDER: S-EPMC3218508 | biostudies-literature | 2011 May-Jun
REPOSITORIES: biostudies-literature
Hansen Thomas B TB Kjems Jørgen J Bramsen Jesper B JB
RNA biology 20110501 3
The immaculate annotation of all microRNAs (miRNAs) is a prerequisite to study their biological function on a genome-wide scale. However, the original criteria for proper miRNA annotation seem unsuited for the automated analysis of the immense number of small RNA reads available in next generation sequencing (NGS) datasets. Here we analyze the confidence of past miRNA annotation in miRBase by cross-analyzing publicly available NGS datasets using strengthened annotation requirements. Our analysis ...[more]