Deep sequencing-based identification of small non-coding RNAs in Streptomyces coelicolor.
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ABSTRACT:
SUBMITTER: Vockenhuber MP
PROVIDER: S-EPMC3218513 | biostudies-literature | 2011 May-Jun
REPOSITORIES: biostudies-literature
Publications
Deep sequencing-based identification of small non-coding RNAs in Streptomyces coelicolor.
Vockenhuber Michael-Paul MP Sharma Cynthia M CM Statt Michaela G MG Schmidt Denis D Xu Zhenjiang Z Dietrich Sascha S Liesegang Heiko H Mathews David H DH Suess Beatrix B
RNA biology 20110501 3
Streptomyces coelicolor is considered the model organism among Gram positive, GC rich bacteria. Its genome has been sequenced but little is known about the occurrence and distribution of small non-coding RNAs in this biotechnologically relevant organism. Using deep sequencing we analyzed the transcriptome at the end of exponential growth, which corresponds to the onset of secondary metabolism. We mapped 193 transcriptional start sites of mRNA genes and identified putative new and alternative ope ...[more]
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