Ontology highlight
ABSTRACT:
SUBMITTER: Kennedy JS
PROVIDER: S-EPMC3218648 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Kennedy Jeffrey S JS Gurwith Marc M Dekker Cornelia L CL Frey Sharon E SE Edwards Kathryn M KM Kenner Julie J Lock Michael M Empig Cyril C Morikawa Shigeru S Saijo Masayuki M Yokote Hiroyuki H Karem Kevin K Damon Inger I Perlroth Mark M Greenberg Richard N RN
The Journal of infectious diseases 20110915 9
<h4>Introduction</h4>LC16m8 is an attenuated cell culture-adapted Lister vaccinia smallpox vaccine missing the B5R protein and licensed for use in Japan.<h4>Methods</h4>We conducted a phase I/II clinical trial that compared the safety and immunogenicity of LC16m8 with Dryvax in vaccinia-naive participants. Adverse events were assessed, as were electrocardiography and laboratory testing for cardiotoxicity and viral culturing of the vaccination sites. Neutralization titers to vaccinia, monkeypox, ...[more]