Sniper: improved SNP discovery by multiply mapping deep sequenced reads.
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ABSTRACT:
SUBMITTER: Simola DF
PROVIDER: S-EPMC3218843 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Sniper: improved SNP discovery by multiply mapping deep sequenced reads.
Simola Daniel F DF Kim Junhyong J
Genome biology 20110620 6
SNP (single nucleotide polymorphism) discovery using next-generation sequencing data remains difficult primarily because of redundant genomic regions, such as interspersed repetitive elements and paralogous genes, present in all eukaryotic genomes. To address this problem, we developed Sniper, a novel multi-locus Bayesian probabilistic model and a computationally efficient algorithm that explicitly incorporates sequence reads that map to multiple genomic loci. Our model fully accounts for sequen ...[more]
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Project description: Not available
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