Caspase deficiency alters the murine gut microbiome.
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ABSTRACT:
SUBMITTER: Brinkman BM
PROVIDER: S-EPMC3219086 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Caspase deficiency alters the murine gut microbiome.
Brinkman B M BM Hildebrand F F Kubica M M Goosens D D Del Favero J J Declercq W W Raes J J Vandenabeele P P
Cell death & disease 20111020
Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp)1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in par ...[more]
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