Ontology highlight
ABSTRACT:
SUBMITTER: Xi R
PROVIDER: S-EPMC3219132 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Xi Ruibin R Hadjipanayis Angela G AG Luquette Lovelace J LJ Kim Tae-Min TM Lee Eunjung E Zhang Jianhua J Johnson Mark D MD Muzny Donna M DM Wheeler David A DA Gibbs Richard A RA Kucherlapati Raju R Park Peter J PJ
Proceedings of the National Academy of Sciences of the United States of America 20111107 46
DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human disorders. Array comparative genomic hybridization has been used widely to identify CNVs genome wide, but the next-generation sequencing technology provides an opportunity to characterize CNVs genome wide with unprecedented resolution. In this study, we developed an algorithm to detect CNVs from whole-genome sequencing data and applied it to a new ...[more]