Ontology highlight
ABSTRACT:
SUBMITTER: Cordero-Morales JF
PROVIDER: S-EPMC3219143 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cordero-Morales Julio F JF Gracheva Elena O EO Julius David D
Proceedings of the National Academy of Sciences of the United States of America 20110919 46
Transient receptor potential (TRP) channels are polymodal signal detectors that respond to a wide array of physical and chemical stimuli, making them important components of sensory systems in both vertebrate and invertebrate organisms. Mammalian TRPA1 channels are activated by chemically reactive irritants, whereas snake and Drosophila TRPA1 orthologs are preferentially activated by heat. By comparing human and rattlesnake TRPA1 channels, we have identified two portable heat-sensitive modules w ...[more]