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Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome.

ABSTRACT: Interactions between genetic regions located across the genome maintain its three-dimensional organization and function. Recent studies point to key roles for a set of coiled-coil domain-containing complexes (cohibin, cohesin, condensin and monopolin) and related factors in the regulation of DNA-DNA connections across the genome. These connections are critical to replication, recombination, gene expression as well as chromosome segregation.

SUBMITTER: Poon BP

PROVIDER: S-EPMC3219537 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome.

Poon Betty P K BP Mekhail Karim K

Cell cycle (Georgetown, Tex.) 20110815 16

Interactions between genetic regions located across the genome maintain its three-dimensional organization and function. Recent studies point to key roles for a set of coiled-coil domain-containing complexes (cohibin, cohesin, condensin and monopolin) and related factors in the regulation of DNA-DNA connections across the genome. These connections are critical to replication, recombination, gene expression as well as chromosome segregation. ...[more]

PMID: 21822055

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