Ontology highlight
ABSTRACT:
SUBMITTER: Babu M
PROVIDER: S-EPMC3219608 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Babu Mohan M Díaz-Mejía J Javier JJ Vlasblom James J Gagarinova Alla A Phanse Sadhna S Graham Chris C Yousif Fouad F Ding Huiming H Xiong Xuejian X Nazarians-Armavil Anaies A Alamgir Md M Ali Mehrab M Pogoutse Oxana O Pe'er Asaf A Arnold Roland R Michaut Magali M Parkinson John J Golshani Ashkan A Whitfield Chris C Wodak Shoshana J SJ Moreno-Hagelsieb Gabriel G Greenblatt Jack F JF Emili Andrew A
PLoS genetics 20111117 11
As the interface between a microbe and its environment, the bacterial cell envelope has broad biological and clinical significance. While numerous biosynthesis genes and pathways have been identified and studied in isolation, how these intersect functionally to ensure envelope integrity during adaptive responses to environmental challenge remains unclear. To this end, we performed high-density synthetic genetic screens to generate quantitative functional association maps encompassing virtually t ...[more]